Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany. German Center for Infection Research (DZIF), Heidelberg Partner Site, Heidelberg, Germany. Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, Stuttgart, Germany. German Center for Infection Research (DZIF), Tübingen Partner Site, Tübingen, Germany. Department of Clinical Pharmacology, University Hospital Tübingen, Tübingen, Germany. Department of Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany. Tytgat Institute for Liver and Intestinal Research & Department of Gastroenterology & Hepatology, Academic Medical Center, Amsterdam, The Netherlands. Experimental and Clinical Toxicology, Saarland University, Homburg, Germany. Institute of Medical Biostatistics and Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany. Myr GmbH, Bad Homburg, Germany. Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Heidelberg, Germany.